MDA-MB-231 cell invasion in the structurally homogeneous matrigel.

<p>(A) The MDA-MB-231 cells attached to the matrigel side surface wall at 0 hours. The red line shows the front of the cell group. (B) MDA-MB-231 cell invasion in the matrigel at 96 hours. The cells and matrigel digestion caused gel shrinkage compared with the cell front at 0 hours. (C) Few cells in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0118058#pone.0118058.g003" target="_blank">Fig. 3B</a> stretched out and exhibited slight invasion into the matrigel, as the white arrows denote, indicating that MDA-MB-231 cells could not invade into the stiff matrigel of 100% concentration.