Genomic distribution of 5mC and 5hmC.

<p>6a: Distribution of 5hmC and 5mC levels at CpG islands, shores (0–2 kb) and shelves (2–4 kb). 5mC levels show a steep rise moving away from CpG sites, 5hmC levels are lowest at CpG sites but show less variation between shores and shelves. The width of the boxes is proportional to the number of underlying probes. 6b: Distribution of 5mC and 5hmC levels around the TSS. Levels of both types of methylation rise steeply moving away from TSS’s.