Model predictions and experiments in various mutant backgrounds.

<p>(A) Predicted vs. experimentally observed flowering time for mutants used in training the model (black) and for double mutants used for validation (red). Wild type flowering time is indicated in green. RL, rosette leaves: the more rosette leaves, the later flowering. (B) Prediction of expression changes; total change in expression over the simulated time-course is calculated, normalized against wild type; absolute value is reported to focus on the magnitude of the predicted expression change. Horizontal axis, mutants; vertical axis, genes for which expression change in mutant background is simulated. Note that FLC and SVP are not regulated by other genes in the model and hence, their expression level does not change upon any mutation. For comparison between predictions and experiments, see Figures C and D in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116973#pone.0116973.s001" target="_blank">S1 File</a>.