DCLK1 expression level is higher in stromal relative to epithelial cells in human PDAC.

<p>A: Paraffin-embedded PDAC tumor sections were immuno-stained with anti-cytokeratin antibody (yellow brown) and anti-DCLK1 antibody (purple) to detect tumor epithelial cells and DCLK1 expression. B: The intensity of DCLK1 expression is stronger in stromal relative to epithelial cells in human PDAC (p = 0.009). The intensity of DCLK1 expression in epithelial cells and stromal cells was scored separately for each specimen and grouped based on cancer stage (n = 10, 12, 12, and 10 for stage I, II, III, and IV respectively). C: DCLK1 mRNA levels are elevated in human pancreatic tumor tissue relative to normal pancreas tissue. DCLK1 mRNA expression levels were summarized and grouped using a published DNA microarray data [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0118933#pone.0118933.ref027" target="_blank">27</a>]. p<0.05.