High progesterone receptor (PGR) density level is associated with reduced clinical failure free survival (CFFS).

<p>Kaplan-Meier curves displaying proportion of prostate caner patients (n = 535) with CFFS according to high and low density level of progesterone receptor (PGR) in different cell types A-D. <b>(A)</b> Tumor stromal cells (TS), <b>(B)</b> tumor cells (TE), <b>(C)</b> TE and TS combined and <b>(D)</b> TE in patients with a high Gleason score (≥ 7). A high PGR density level is significantly associated with a reduction in CFFS. In both TE and TS, cut off was defined as the density level × 4^th quartile. A high score was defined as density level ≥ 0.75 in TE, and ≥ 1.75 in TS. Log-rank tests were used to assess the statistical significance between the survival curves of the model. Median follow-up time was 89 (range 6–188) months. A p-value < 0.05 was considered statistically significant.