Characterization of the disease response hub genes extracted from the Arabidopsis co-expression network.

<p>(<b>A</b>) Unweighted network showing the connectivity (TOM > 0.1) between the 46 hub genes identified in the LTDL, PB, TOOL, and LT meta-modules and 20 extended hub genes (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0118731#pone.0118731.s012" target="_blank">S7 Table</a>). Nodes are visualized as circles and correlations between nodes as lines (edges). Node size is proportional to degree of unweighted connectivity; the colors of the nodes correspond to modular assignments. The inner circle represents the disease response-related meta-module hub connectivity. The outer circle represents the extended hub genes found to have TOM > 0.1 connections with > 75% of the original hubs. (<b>B</b>) Gene Ontology-annotated hierarchy of the top 5% enriched biological processes in the 66 hub genes. Boxes represent direct assignments of GO terms to hub genes, and ellipses represent parent terms assigned by topGO during analysis. (<b>C</b>) Boxplot showing the distribution of gene expression fold changes (log₂) of the hub nodes in each microarray. The modules associated to each of the genes are provided in the multi-color bar. Red and blue dots represent comparisons in which genes were up- and down-regulated, respectively. For details refer to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0118731#pone.0118731.s012" target="_blank">S7 Table</a>.