Location of residues discussed in the manuscript on the overall structure of the complex between the α-chain and AHSP and on the structure of the αβ dimer.

<p><b>A:</b> Cartoon representation of the three-dimensional structure of the complex between the α-chain and AHSP (PDB code 1Y01) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115738#pone.0115738.ref003" target="_blank">3</a>]. The α-chain of HbA is highlighted in cyan, whereas the AHSP molecule is in green. In this structure the position of residues 1, 74, 81–91 and 140–142 in the α-globin chain of HbA has not been determined. For this reason the structural representation lacks these residues. <b>B:</b> Cartoon representation of the three-dimensional structure of the αβ dimer from the structure of the tetrameric human deoxy hemoglobin (PDB code 2HHB) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115738#pone.0115738.ref023" target="_blank">23</a>]. α- and β-chains are highlighted in cyan and yellow, respectively.