Features of CLL patients with clinical Binet Stage B/C.

<p><i>IGHV</i> mutational status homology ≥ 98%: M, mutated; UM, unmutated. ZAP70 is considered negative when the ratio (<i>R</i>) of mean fluorescence of T lymphocytes/mean fluorescence of CLL B lymphocytes ≥ 12. ZAP70 is considered positive if <i>R</i> ≤ 10, and “grey zone” if 10 < <i>R</i> < 12. CD38 is considered positive when the percentage of positive leukemic cells is ≥30%. FISH: score of interphasic cells with an abnormality. Complex karyotype is ≥3 chromosomal abnormalities. bi, biallelic; Del, deletion; mono, monoallelic; nd, not done.</p><p>Features of CLL patients with clinical Binet Stage B/C.