Proposed model for compression-induced dephosphorylation of myosin regulatory light chain (MRLC).
- Kenji Takemoto (697411)
- Seiichiro Ishihara (443424)
- Takeomi Mizutani (443427)
- Kazushige Kawabata (443429)
- Hisashi Haga (443431)
Publication date
March 2015
DOIAbstract
<p>In C2C12 cells subjected to compressive loading, RhoA and adenylyl cyclase activation were induced. Adenylyl cyclase activation may activate protein kinase A (PKA) via cAMP production. RhoA phosphorylation by PKA induces decreasing affinity of RhoA for ROCK and inactivates ROCK [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0117937#pone.0117937.ref019" target="_blank">19</a>]. Myosin phosphatase target subunit 1 (MYPT1) at Thr852 which is kinase substrate of ROCK is dephosphorylated. Accordingly, myosin phosphatase (MLCP) is activated and dephosphorylates MRLC.</p
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