Effect of XGB on basal metabolic rate in wild type and <i>Tgr5</i>^-/- mice fed chow or WD diet.

<p>VO2 was measured during the dark and light phases of the diurnal cycle in thermoneutral conditions (18, 25). Panel A shows animals fed a control chow diet and panel B represents animals fed the WD. There were 5 to 6 mice per group. White bars represent sham—operated mice and black bars represent mice subjected to XGB. The experiment was independently repeated three times with equivalent results. Values represent the mean ± S.E.M. * p < 0.02 compared with the XGB mice; ^# p < 0.05 compared with the wild type animals (two-way ANOVA).