DZNep impairs cell growth of B-cell lymphoma cells.

<p>(<b>A</b>) Necrosis of cells treated as indicated was determined according to lactate dehydrogenase release in the supernatant. (<b>B</b>) Cell viability was determined by calcein AM staining (esterase activity analysis) of cells treated as indicated, and the apoptotic cell population (reduced esterase activity) is indicated in representative histograms. (<b>C</b>) Cells were incubated with DZNep (0.2, 1, 3, or 5 μM) alone for 40 h, and cell proliferation was determined by CellTiter 96 assay.