Main effect of carrying <i>APOE</i> ε4 on brain structure in Chinese and white subgroups.
- Jennifer S. Yokoyama (135343)
- Allen K. L. Lee (698573)
- Leonel T. Takada (698574)
- Edgar Busovaca (298292)
- Luke W. Bonham (698575)
- Steven Z. Chao (698576)
- Marian Tse (698577)
- Jing He (58446)
- Christopher G. Schwarz (698578)
- Owen T. Carmichael (698579)
- Brandy R. Matthews (698580)
- Anna Karydas (531627)
- Michael W. Weiner (361438)
- Giovanni Coppola (46572)
- Charles S. DeCarli (698581)
- Bruce L. Miller (297862)
- Howard J. Rosen (418693)
Publication date
March 2015
DOIAbstract
<p>T-maps from cohort-specific analyses are shown at P<sub>uncorrected</sub><0.01 overlaid on a template brain in MRICron. Whites are shown in yellow (T range 2.39–4.84), Chinese Americans in blue (T range 2.44–4.91), and Shanghai Chinese are in red (T range 2.50–3.14). Left side of image corresponds to left side of brain, with Montreal Neurological Institute (MNI) coordinates provided for respective slices. Both Chinese groups showed suggestive volume reductions in precuneus/cuneus in <i>APOE</i> ε4 carriers versus non-carriers. Chinese Americans also showed lower volume in the hippocampal formation.</p
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