Reversion rates of <i>trp5-G148T</i> and <i>trp5-A149C</i> diploid strains show major increases only when lacking both MMR and one proofreading activity.

<p>Reversion rates of diploid strains with the indicated genotypes were determined as detailed in Materials and Methods. All indicated mutations are homozygous. Error bars represent 95% Confidence Intervals. F and R refer to the orientation of the hemizygous <i>TRP5</i> gene relative to the <i>ARS306</i> origin of replication. (A) <i>trp5-G148T</i> strains; data are given in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005049#pgen.1005049.s001" target="_blank">S1 Table</a>. (B) <i>trp5-A149C</i> strains; data are given in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005049#pgen.1005049.s002" target="_blank">S2 Table</a>.