BMS-754807 inhibits proliferation and reduces viability of DIPG neurospheres in a dose-dependent manner.
- Kyle G. Halvorson (699837)
- Kelly L. Barton (465812)
- Kristin Schroeder (699838)
- Katherine L. Misuraca (699839)
- Christine Hoeman (699840)
- Alex Chung (699841)
- Donna M. Crabtree (699842)
- Francisco J. Cordero (699843)
- Raj Singh (103123)
- Ivan Spasojevic (230788)
- Noah Berlow (699844)
- Ranadip Pal (590374)
- Oren J. Becher (357399)
Publication date
March 2015
DOIAbstract
<p>Cells were isolated from mouse DIPG induced by PDGF-B, H3.3K27M, and p53 loss (PKC) or PDGF-B; H3.3WT, and p53 loss (PHC), cultured <i>in vitro</i> as neurospheres, treated with BMS-754807 or vehicle at the indicated doses for 48 hours, and assayed for (A) cell proliferation using BrdU incorporation and (B) cell viability using Cell Titer Glo. All statistics were compared to 0 μm.</p
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