Inhibition of MEK/ERK signaling in α3β1-expressing MK cells increases relative expression of the long MMP-9 mRNA variant.

<p>(A) Representative western blot showing inhibition of phospho-ERK (<i>pERK</i>) with U0126 compound in MK+/+ cells, compared with DMSO control; <i>ERK</i>, total ERK; positions of molecular weight markers are indicated at right (kDa). (B) Quantification of RPA (performed as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119539#pone.0119539.g003" target="_blank">Fig. 3</a>) showing the effects of ERK inhibition in MK+/+ cells on the relative amount of the long MMP-9 mRNA variant. Data are mean ± s.e.m. (n = 6); all values were normalized through dividing by the average for the control (DMSO). *P<0.05, Student’s two-tailed t-test.