Leptin deficiency does not impair the whole body heat production response to cold stress in mice.

<p>(<b>A</b>) Energy expenditure across all photoperiods, (<b>B</b>) photoperiod-averaged energy expenditure (EE) profiles and (<b>C</b>) the relationship between energy expenditure and ambient temperature in adult male <i>ob/ob</i> mice and wild-type (WT) littermate controls housed under different ambient temperature conditions (n = 8/group). (D) Regression of natural log (ln) of mean 24h EE values on the natural log of the mean difference between core temperature (Tc) and ambient temperature (Ta) (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119391#pone.0119391.s001" target="_blank">S1 Fig.</a>). Mean±SEM. ****p<0.0001, ***p<0.001, **p<0.01.