Leptin signaling is required for adaptive changes in energy intake in response to a thermal challenge.

<p>(<b>A</b>) Photoperiod-averaged energy intake profiles and (<b>B</b>) the relationship between energy intake and ambient temperature in adult male <i>ob/ob</i> mice and wild-type (WT) littermate controls housed under different ambient temperature conditions (n = 8/group). Mean±SEM. ***p<0.001, *p<0.05.