Leptin deficient animals are unable to maintain energy homeostasis in response to a thermal challenge.

<p>(<b>A</b>) Study design, (<b>B</b>) body weight, (<b>C</b>) fat mass, (<b>D</b>) change in body weight, (<b>E</b>) change in fat mass and (<b>F</b>) change in lean body mass in adult male <i>ob/ob</i> mice and wild-type (WT) littermate controls housed under different ambient temperature conditions (n = 8/group). Arrowheads mark measures of body weight and composition. Mean±SEM. ****p<0.0001, ***p<0.001, *p<0.05.