<p>(A) Mutations made across the conserved region of <i>hctA</i> resulted in the mutant <i>hctA</i>6–27. Each mutation was designed to maintain the amino acid structure whilst disrupting the linear RNA sequence of the potential target region for IhtA. (B) Mutant <i>hctA</i> constructs were co-transformed with empty pLac vector or wild type <i>ihtA</i> into <i>E</i>. <i>coli</i> and assayed for growth upon induction of HctA expression. Wild type <i>hctA</i> co-transformed with pLac or <i>ihtA</i> served as controls. Cell viability was expressed as a percentage of the ratio between the induced and uninduced samples. Each condition was performed in triplicate over at least three separate experiments. The bars represent the mean ± SEM of the tr...
<p>(<b>A</b>) Selected amino acid changes identified following transfection of a selectable subgenom...
<p><b>(A)</b> Schematic of the native (above) and mutant (below) siRNA 3570 target sites in the HCV ...
<p>(A) Schematic of the <i>AAH2</i> knockout strategy in the wild-type ME49 <i>Δhxg</i>::<i>Luc</i> ...
<p>(A) Schematic of the mutations made in IhtA and the corresponding compensatory mutations made in ...
<p>(A) Schematic of the UTR of pTet compared to the 5’ UTR, starting at the TSS of <i>C</i>. <i>trac...
<p>A) Growth viability of <i>E. coli</i> co-expressing serovar L2 HctA and <i>C. trachomatis</i> ser...
<div><p>The non-coding small RNA, IhtA expressed by the obligate intracellular human pathogen <i>Chl...
<p>The coding sequence for full length wild type SIRT6 and the H133W mutant was PCR-amplified and cl...
<p><b>[A]</b> Htz1 C-terminal mutants are sensitive to cytotoxic stress. To compare the growth of st...
<p>(A) Scheme for <i>jhamt</i> targeting. <i>jhamt</i> (black box) is replaced with <i>white</i> (gr...
<p>(<b>A</b>) The <i>hcr1Δ</i> strain was transformed with either empty vector (EV), hc <i>HCR1</i> ...
<p>The effect of ALDH3A1 on cell proliferation was investigated in Tet-On hTCEpi cell lines induced ...
<p>(A) A yeast cancer-ortholog synthetic lethal network. Lines indicate synthetic lethal genetic int...
<p>(A) Effect of mutations impairing DNA polymerases on HC formation. Results of 3 to 14 experiments...
<p>(A) The three T-DNA insertions in <i>HTA8</i>, <i>HTA9</i>, and <i>HTA11</i>. Exons are represent...
<p>(<b>A</b>) Selected amino acid changes identified following transfection of a selectable subgenom...
<p><b>(A)</b> Schematic of the native (above) and mutant (below) siRNA 3570 target sites in the HCV ...
<p>(A) Schematic of the <i>AAH2</i> knockout strategy in the wild-type ME49 <i>Δhxg</i>::<i>Luc</i> ...
<p>(A) Schematic of the mutations made in IhtA and the corresponding compensatory mutations made in ...
<p>(A) Schematic of the UTR of pTet compared to the 5’ UTR, starting at the TSS of <i>C</i>. <i>trac...
<p>A) Growth viability of <i>E. coli</i> co-expressing serovar L2 HctA and <i>C. trachomatis</i> ser...
<div><p>The non-coding small RNA, IhtA expressed by the obligate intracellular human pathogen <i>Chl...
<p>The coding sequence for full length wild type SIRT6 and the H133W mutant was PCR-amplified and cl...
<p><b>[A]</b> Htz1 C-terminal mutants are sensitive to cytotoxic stress. To compare the growth of st...
<p>(A) Scheme for <i>jhamt</i> targeting. <i>jhamt</i> (black box) is replaced with <i>white</i> (gr...
<p>(<b>A</b>) The <i>hcr1Δ</i> strain was transformed with either empty vector (EV), hc <i>HCR1</i> ...
<p>The effect of ALDH3A1 on cell proliferation was investigated in Tet-On hTCEpi cell lines induced ...
<p>(A) A yeast cancer-ortholog synthetic lethal network. Lines indicate synthetic lethal genetic int...
<p>(A) Effect of mutations impairing DNA polymerases on HC formation. Results of 3 to 14 experiments...
<p>(A) The three T-DNA insertions in <i>HTA8</i>, <i>HTA9</i>, and <i>HTA11</i>. Exons are represent...
<p>(<b>A</b>) Selected amino acid changes identified following transfection of a selectable subgenom...
<p><b>(A)</b> Schematic of the native (above) and mutant (below) siRNA 3570 target sites in the HCV ...
<p>(A) Schematic of the <i>AAH2</i> knockout strategy in the wild-type ME49 <i>Δhxg</i>::<i>Luc</i> ...