IL-1RI and IL-18-deficient mice are more susceptible to lung infection with <i>Ft</i> LVS.

<p>(A) C57BL/6J or <i>Il-1r1</i>^-/- mice (<i>n =</i> 11), <i>or Il-18</i>^-/- and <i>Il-1r1</i>^-/-/<i>Il-18</i>^-/- (DKO) mice (<i>n</i> = 5) were intranasally infected with 4x10³ CFU <i>Ft</i> LVS and survival was monitored. (B) Mice infected as in A were euthanized 72 hours or 6 days p.i. and bacterial burden in organs was measured. One representative experiment of two is shown. Data are expressed as mean + S.D. *<i>p</i><0.05, **<i>p</i><0.01. (B) Mann-Whitney U test.