Deletion of JunB and c-Jun in oligodendrocytes.

<p>(a) Schematic diagram of MOGiCre x JunB^f/f and c-Jun^f/f (JunB^Δol/Jun-c^Δol) mice. (b) Genotyping PCR using genomic DNA derived from various peripheral organs and CNS regions from a JunB^flox/flox (top) and c-Jun^flox/flox (bottom) MOGiCre/+ mutant (JunB^Δol/c-Jun^Δol) and from a homozygous JunB^flox/flox/c-Jun^flox/flox MOGiCre-negative control (JunB^f/f/c-Jun^f/f). Li, liver; Ki, kidney, Spl, spleen; Hr, heart; Thy, thymus, Lu, lung; Ln, lymph node; Br, brain; Cb, cerebellum; Sc, spinal cord. (c) Western Blot analysis for JunB, c-Jun and vinculin (loading control) in protein lysates obtained from CNS spinal cord tissue of junB^f/fc-Jun^f/f controls and JunB^Δol/c-Jun^Δol double mutants (n = 2 individual animals per group).