Comparison of conformations between DENV3 NS5 and JEV NS5 structures.

<p><b>(A)</b> and <b>(B)</b> Side-by-side view of the DENV3 NS5 and the JEV NS5 structures in thin ribbon style. Same color scheme as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004682#ppat.1004682.g001" target="_blank">Fig. 1</a>: MTase is in yellow, RdRp fingers in green, palm in blue, thumb in salmon. The linker regions (260–271 in DENV3 NS5; 263–274 in JEV NS5) are shown as cartoon in red. Missing residues (407–417 and 455–468 in DENV3 NS5; 271–273 in JEV NS5) are indicated as dots. The rotation axis that relates both MTase domains is indicated with the corresponding angle. <b>(C)</b> The simulated annealing mF_obs-DF_calc omit maps are in green, contoured at 3σ and in magenta, contoured at 5σ. <b>(D)</b> Sequence conservation of the linker region of DENV 1–4 and representative flaviviruses. Figure is generated with WebLogo [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004682#ppat.1004682.ref071" target="_blank">71</a>].