LTD responses induced by a HFS protocol are not modulated by D1Rs and 5-HT1ARs in the PFC.

<p>(A) LTD responses induced in L5PyNs from129/Sv mice recorded for 15 min, 30 min, 45 min and 60 min after the HFS protocol. Histograms represent relative conductance changes (compared to resting condition) of IntgT (black bars), IntgE (red bars) and IntgI (blue bars). (B) LTD responses induced in L5PyNs from 5-HT_1AR-KO mice. (C) LTD responses induced in L5PyNs from 129/Sv mice in the presence of SCH 23390 (10 μM) recorded for 15 min, 30 min, 45 min and 60 min after the HFS protocol. Histograms represent relative conductance changes (compared to the resting condition following 15 min pre-incubation of the antagonist <i>i</i>.<i>e</i>. 100%), IntgT (black bars), IntgE (red bars) and IntgI (blue bars). (D) LTD responses induced in L5PyNs from 5-HT_1AR-KO mice in the presence of SCH 23390 (10 μM). (E) LTD responses induced in L5PyNs from 129/Sv mice in the presence of SKF 81297 (10μM). Histograms represent relative conductance changes (compared to the resting condition following 15 min pre-incubation of the agonist <i>i</i>.<i>e</i>. 100%), IntgT (black bars), IntgE (red bars) and IntgI (blue bars). (F) LTD responses induced in L5PyNs from 5-HT_1AR-KO mice in the presence of SKF 81297 (10 μM). Error bars represent S.E.M. (* p < 0.05, ** p < 0.01;*** p<0.001).