Reversal of the effects of UFH on the arterial thrombosis in rats.

<p>Dry thrombus weight in Wistar rats treated with vehicle (PBS), UFH in dose of 300 or 900 U· kg^-1) alone or followed by Dex40-GTMAC2 (4.2 mg·kg^-1), Dex40-GTMAC3 (2.5, 7.5 or 22.5 mg·kg^-1), Dex6-GTMAC (9.6 mg·kg^-1), GCD-GTMAC2 (10.8 mg·kg-1), and protamine (3.0 mg·kg^-1), c-P<0.001 vs. vehicle; d-P<0.05, e-P<0.01 vs. UFH 300 U·kg^-1; l-P<0.001 vs. UFH 900 U·kg^-1, Mann-Whitney test. Results are shown as mean ± SD, n = 8–10.