IL-1RA contributes to control of <i>Y</i>. <i>pestis</i> replication and pathology in the lung.

<p><b>A.</b> Histology of fixed H&E stained lung sections from mice at 24 hpi with <i>Y</i>. <i>pestis</i>, +/- IL-1RA nAb. Small foci of inflammation indicated by arrows. <b>B.</b> Inflammation from histopathology sections was quantified as described in Methods. <b>C</b>. Bacterial burdens were assessed from mice 24 hpi with <i>Y</i>. <i>pestis</i>, +/- IL-1RA nAb. <b>D</b>. Cytokine analysis from lysates of homogenized lungs of mice infected with <i>Y</i>. <i>pestis</i> +/- IL-1RA nAb for 24 hrs was perfomed by ELISA (BD Pharmingen). * p<0.05, ** <i>p</i><0.001.