Longitudinal comparison.

<p>A) Absolute difference maps (mm) in each group. In CTR and sMCI, both pipelines report a very mild and widespread cortical thinning rate in the motor, somatosensory, verbal and visual association cortex. In pMCI, the atrophy peaks at rates around 0.3 mm in the medial temporal cortex, temporal-parietal-frontal neocortices, with sparing of the sensorimotor strip and of the visual cortex. In AD, the atrophy in the same areas accelerates beyond 0.4 mm. B) Disease effect maps. The mean estimate of the longitudinal disease effect in CTR and sMCI as computed by Freesurfer is greater, although Civet shows higher results in few scattered areas. Furthermore, in the entire disease spectrum, Freesurfer exhibited higher disease effect in the motor cortex. In pMCI, Civet exhibits a greater disease effect except for the cingulate gyrus, while in the AD group the exception is represented by the precuneus. C) Statistical difference maps (p<0.01 FDR-corrected). In CTR, Civet detects an atrophic cluster in the angular gyrus; while Freesurfer in the precuneus and in the temporo-occipital lobe. The pattern in sMCI was more reduced than in CTR. In pMCI Freesurfer was not able to find many regions detected by Civet with the same significance and extension (i.e.: orbital, triangulal, and opercular portion of the inferior frontal gyrus, transverse-temporal and mesial part of the superior frontal cortex, inferior parietal cortex, the superior temporal gyrus). Freesurfer was more sensitive in few scattered expected and unexpected regions. For both pipelines, the longitudinal AD shrinkage showed significant areas throughout the temporal, frontal and parietal lobes, consistently with the progression of the disease. Some shrivelling differences were detected in the anterior division of the cingulate, in the limbic lobe and in the cuneus. D) Overlapping and not-overlapping atrophic regions are shown. Significant voxels detected by both pipelines are in yellow; voxels detected only by Civet are in blue; voxels detected only by Freesurfer are in red. CV: Civet; FS: Freesurfer; L: Left hemisphere; R: Right hemisphere; CTR: Normal elderly controls; sMCI: stable MCI; pMCI: progressive MCI; AD: Alzheimer’s Disease.