OPLS-DA analysis of serum ¹H NMR data of LT-12, LT-6, LT-2, MT-2 and HT-2 groups in couple with NC group: score plots (a, c, e, g and i) and loading plots (b, d, f, h and j).

<p>In score plots, ellipses around sample points stood for the 90% confidence. Metabolite variation was visualized by the loading plots, which are color-coded according to the absolute value of the correlation coefficient; a reddish signal indicates a more significant contribution to the class separation than a bluish signal. Metabolites: 1, LDL/VLDL; 2, 3-HB 3, Lactate; 4, Alanine; 5, Arginine; 6, Acetone; 7, Creatine; 8, Taurine; 9, Betaine; 10, Glucose.