Analysis of human immune cells in HIS and HIS-HUHEP mice.

<p>The (A) percentage and (B) total number of hCD45⁺ cells in the bone marrow (BM), thymus, spleen, liver and lymph nodes (LN) in HIS and HIS-HUHEP mice were determined. Absolute numbers of lymphocyte subsets in the (C) spleen and (D) liver of HIS and HIS-HUHEP mice. (E) Total human IgM and IgG concentrations were measured in the plasma of humanized mice. Error bars show standard deviation. (F) Relative proportions of CD4⁺ T_H and CD8⁺ T_C cell subsets within total CD3⁺ T cells in the liver and spleen of HIS and HIS-HUHEP mice. (G) Relative percentages of naive (CD45RA⁺ white bar) or memory (CD45RO⁺ black bar) CD3⁺ T cells in the liver and spleen of HIS and HIS-HUHEP mice. No statistically significant differences were observed between the HIS and HIS-HUHEP groups (unpaired t tests).