Efficacy of AUY922 in HCC827/GR and HCC827/ER tumor xenograft models.

<p><b>A</b>, SCID mice with established HCC827/GR and HCC827/ER tumor cell xenografts were treated with AUY922. Tumor size was measured on the indicated days, and tumor volume was calculated. Arrows mean last day of drug treatment (red arrow, HCC827/GR; purple arrow, HCC827/ER). Bars represent the mean tumor volume ± SD. <b>B</b> and <b>C</b>, Immunohistochemical staining for Ki-67 and TUNEL followed by quantitative analysis of proliferation and apoptosis in (B) Ki-67⁺ cells and (C) TUNEL⁺ cells. <i>*p</i>< 0.01 and <i>**p</i>< 0.001 in comparison with the control.