Simulation of the selection of <i>trans</i>-acting genes or elements at the tissue infection level.

<p>(A) A summary of the conditions used for the simulations. (B) Assumption of the probability of successful infection at a given ratio of adaptive genomes to the total number of intracellular genomes. (C) Comparison of the rate of adaptation under conditions 1–3. (D) Comparison of the rate of adaptation under conditions 1 and 2 with conditions assuming a fixed founder number and equal progeny accumulation. Data in panels C and D are presented as means ± SE, which were calculated by bootstrap analysis of 1,000 simulated cells. An R script used to generate panels C and D is shown in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002094#pbio.1002094.s032" target="_blank">S6 Text</a>, and the data obtained by the authors are shown in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002094#pbio.1002094.s003" target="_blank">S3 Data</a>.