Over-expression of CAST reduces infarction size.

<p>(A) Representative Evans blue stained hearts from the calpastatin (CAST) transgenic (TG) mice and wild-type (WT) littermates at 24 hours after surgery. (B) Quantification of infarct size at 24 hours after surgery. (C) Gross hearts and hematoxylin & eosin staining of CAST TG mice and WT littermates in sham and myocardial infarction (MI) group. (D) The infarct size of left ventricle for the TG mice and WT mice. (E) Survival of the mice. Data are expressed as means ± SE. **P < 0.01 vs. WT group.