Over-expression of CAST suppresses calpain expression and activity.

<p>(A) Representative Western blots of calpain-1, calpain-2 and calpastatin (CAST) of the heart tissue from the CAST transgenic (TG) mice and wild-type (WT) littermates subjected to sham and myocardial infarction (MI) surgery. (B) Calpain activity in the myocardial tissue. Data are expressed as means ± SE. **P<0.01 vs. WT-Sham group, ^##P<0.01 vs. WT-MI group.