PB + PER reduced SYP staining in the hippocampi and cerebral cortices of exposed mice 18 day post-exposure.

<p>Reduced SYP staining was observed in the CA3 region of exposed mice (B) versus controls (A) at 18 days post exposure (Welch’s t-test = 84.08, DF = 1, p < 0.001). In addition, significantly reduced SYP staining was evident in the cerebral cortices of exposed mice (D), as compared to controls (C) (Welch’s t-test = 18.31, DF = 1, p = 0.02). Representative images were taken at 60X magnification (scale bars represent 1 mm). Inset depicts positive SYP staining showing dark brown pre-synaptic vesicles stained within the cell soma (see inset in A and C). Histograms depict the quantification of the SYP stain in the hippocampi and cerebral cortices, as % Area per microscopic field, and error bars show standard error of the mean (SEM).