Effects on neuronal density and morphology.

<p>A) Representative images of rigid, flex and flex embedded mode implantations after 6 weeks, showing mode dependent alterations neuronal densities, as shown in green (NeuN), total cell nuclei (DAPI) in blue and merged (GFAP in red depicting the implantation scar). Scale bar: 50 μm. B and C) Quantification of the NeuN and DAPI densities, respectively, that surrounds the different implantation sites at the inner ROI (0–50 μm). Note that in B) the NeuN densities are compared to paired naïve areas (controls). The box corresponds to the 25th and 75th percentiles, the median value is indicated by the horizontal line within each box, and the whiskers show the minimum and maximum values. The horizontal lines indicate statistical differences.