Dose-dependent, Reversible, and Erythroid Lineage-Specific Effect of CID on <i>In Vivo</i> Erythropoiesis.

<p>(A) Changes in the reticulocyte counts in the peripheral blood of the line A transgenic mice by intraperitoneal injection of CID (10.0, 1.0, or 0.1 mg/kg) or vehicle every day for 9 days (arrowheads). Reversible and dose-dependent induction of the reticulocyte counts by CID administration was observed. (B) The levels of reticulocytes, hematocrit, platelets, and white blood cells (WBC) in the peripheral blood of line A transgenic mice were counted before (Day0) and after (Day10) daily intraperitoneal injections of CID (10 mg/kg), rHuEPO (300 U/kg), or vehicle for 9 days (Days 1–9). These assays were performed in triplicate (3 mice for each group) and repeated 3 times. The results are shown as the mean ± standard deviations. *p < 0.01 compared with Day0 (hatched bars).