Administration of 6-paradol reduces microglial activation in the post-ischemic brain 1 day after M/R challenge.

<p>Mice were challenged with M/R and 6-paradol (10 mg/kg, p.o.) was administered immediately after reperfusion. Microglial activation was assessed 22 h after reperfusion by immunohistochemistry against Iba1. (A) Representative images of Iba1-immunopositive cells in periischemic (‘P’) and ischemic core (‘C’) regions. Scale bars, 200 μm (top panels) and 50 μm (middle and bottom panels). (B) Quantification of Iba1-immunopositive cells in both regions. n = 4~5 per group. **p<0.01, versus vehicle-administered M/R mice (M/R+veh).