JSI-124 inhibits activation of VEGFR2 and JAK2/STAT3 signaling induced by VEGF in HUVECs.
- Guang Yuan (706248)
- Shaofeng Yan (706249)
- Hao Xue (303100)
- Ping Zhang (86495)
- Jintang Sun (706250)
- Gang Li (34549)
Publication date
March 2015
DOIAbstract
<p>(A) JSI-124 suppressed the activation of VEGFR2 induced by VEGF in HUVECs in a dose-dependent manner by western blot analysis. (B) Inhibition p-VEGFR2 by JSI-124 resulted in an inhibition of JAK2/STAT3 pathway activation triggered by VEGF in HUVECs dose-dependently by western blot analysis. GAPDH was shown as loading control.</p
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