Mutations in EGFR across 5 different cancers with protein structure context.

<p>(A) The histogram displays the proportions of mutation counts detected at each residue to the total number of mutations that fall in the four different domains encoded by the gene EGFR, in five different cancers. The x-axis indicates the position of mutant residues. Mutations in different domains are shown in different colors. (B) shows the structure of the EGFR protein with epidermal growth factors colored in orange. The arrows point to enlargments of portions of the protein. The tails of the kinase domain are not shown in this structure. The structure visualization was based on Protein Data Bank structure models 1nql, 1ivo, 2jwa, 1m17 and 2gs6[<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004147#pcbi.1004147.ref047" target="_blank">47</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004147#pcbi.1004147.ref050" target="_blank">50</a>]. Significantly-mutated domain instances (SMDs) were shown as thicker boxes.