(A) Sizes of the dissected tumors from different groups of A549 cells growing in mice.

<p><b>(B)</b> Tumor volume change in different groups of A549 cell injections. <b>(C)</b> Tumor weight change in different groups. Data are means ± SD. Double asterisks indicate values that are significantly different from NC group (P < 0.05). <b>(D)</b> Proliferating cell nuclear antigen, Caspase 3 and ENTPD5 expression status in different animal model groups determined by Western blotting. <b>(E)</b> Immunohistochemistry tests showing ENTPD5, Caspase 3 and proliferating cell nuclear antigen expression status in different animal model groups. <b>(F)</b> Apoptosis of tumor tissue cells in animal models after the knockdown of ENTPD5 determined in situ using TUNEL assay.