Systematic epigenetic regulation of MHC class II genes.

<p>A) Genome browser snapshot of a 841,000 bp region from the MHC class II locus located on chromosome 6 (6:32,347,232–33,188,204): Top panel shows the gene models. For two patients (red; #P1 and #P2) and four controls (blue; #C1-#C4) we show normalized ChIP-seq coverage vectors for 3 modifications (H3K4me3, H3K27me3 and H3K9ac). We indicate three regions (grey filled boxes) showing a clear reduction of active marks (H3K4me3 and H3K9Ac). B) Boxplots show log2-transformed average binding changes for three modifications for all MHC genes (left) in comparison to all genes as control (right). C) Genome browser snapshot of an 80,000 bp region from the CIITA gene locus: Top panel shows the gene models. In comparison between patients and controls we identified reduced H3K4me3 binding across the promoter region of the CIITA gene.