Exendin-4 treatment improves endogenous GLP-1 production, reduces glucagon release and improves triglyceride profile.

<p>Blood sampling was performed on day 7 and 15 of treatment -/+ exendin-4 with a low (20μg/kg/day) or high (200μg/kg/day) dose. Analysis of selected metabolic parameters was performed and the difference (∆) between day 7 and 15 was calculated for each mouse as indicated in methods for (a) GLP-1, (b) glucagon, (c) triglycerides and (d) total cholesterol. Results are expressed as mean ±SD. * p<0, 05, ** p<0, 01, *** p<0, 001 by one-way ANOVA followed by Bonferroni correction vs. saline treated control.