Pre-seeded scaffolds promote more effective tissue regeneration.

<p><b>(A)</b> A cross-section of rat skin tissue undergoing the wound-healing process. Black dashed lines designate junctions between abnormal tissue and normal skin morphology. Scale bar = 40 μm. <b>(B)</b> Graph depicts average abnormal tissue areas (<i>n</i> = 5 rats per group) of harvested tissues containing porous scaffolds seeded for 4 days with fibroblasts (4d), porous scaffolds seeded for 1 day (1d), acellular porous scaffolds, and sham wounds. A repeated measure Anova was performed to compare significance between treatment groups. *Represents p<0.01 for all treatment groups that are significantly different from each other within the same time point. Also, all treatment groups significantly decreased over time (p<0.001).