Model of WT1 mRNA regulation by hypoxia.

<p>This schematic diagram shows HIF-1 binding to the HRE in the WT1 promoter (1; requirement of HIF-1α demonstrated in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119837#pone.0119837.g004" target="_blank">Fig. 4</a>), which leads to demethylation of the CpG island in Intron 1 (2; role of demethylation demonstrated in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119837#pone.0119837.g001" target="_blank">Fig. 1</a>), resulting in expression of the lncRNA (3; expression shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119837#pone.0119837.g003" target="_blank">Fig. 3</a>), which induces mRNA expression (4; requirement of lncRNA for mRNA expression is shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119837#pone.0119837.g006" target="_blank">Fig. 6</a>).