Loss of PAI-1-Vn interaction decreases proinflammatory cytokine and chemokine production after LPS challenge.

<p>Mice were challenged with LPS for 6 and 24 hr. (A) Real-time RT-PCR analysis of renal cytokine and chemokine mRNA. Data are expressed as mean ± SEM (N = 6–7 mice per group), *P<0.05. (B) ELISA assays of plasma levels of cytokine and chemokine in mice after LPS challenge. Values shown are mean ± SEM (N = 5 mice per group), *P<0.05.