Effect of leptin on wound healing in mouse skin.

<p>(A) Chemical wounds created in mouse back skin by applying two pieces of filter paper (12x12mm each) soaked with 20% sodium hypochlorite for 5 minutes. (B and C) Skin wound healing at day 4 after wound creation. No significant difference in wound healing was noted between leptin-treated group and control group. Values are mean ± SE from 12 animals per group. (D and E) Skin wound healing at day 8 after wound creation. Significantly enhanced re-epithelialization of the wound was observed in leptin-treated group compared with control group. Values are mean ± SE from 12 animals per group. **P < 0.01. (F) Histological findings during wound repair at day 8 after wound creation. Spaces between the two arrowheads show ulcerated area without epithelial lining. H-E staining. (a) Leptin-reated group. (b) Control group. Scale bars = 500 μm.