T-817MA ameliorated PPI deficits in PDGFR-β KO mice.

<p>(A) Acoustic startle amplitudes measured in trials without a prepulse. No significant differences were observed in the acoustic startle amplitudes among the four groups of mice. Values indicate the mean ± SE. (B) PPI (% inhibition) at five different prepulse intensities (70, 72, 74, 78, and 82 dB). Statistical results by three-way ANOVAs indicated significant main effects of genotype and treatment. Cont-DW, control mice with distilled water (DW); Cont-T817, control mice with T-817MA; KO-DW, PDGFR-β KO mice with DW; KO-T817, PDGFR-β KO mice with T-817MA.