β-HPV 5 and 8 E6 increases sensitivity to ionizing radiation and PARP1 inhibition.

<p>(A.)–(C.) Relative viability of HFK cells exposed to either (A.) ionizing radiation (2 gray) or grown in media with PARP1 inhibitors (10 nM) (B.) AZD 2281 (AZD) and (C.) ABT 888 (ABT). n ≥ 3. Error bars represent standard errors of the mean. * denotes data that is statistically different from the similarly treated vector control as determined by student T-test with a p value ≤ 0.05. # denotes data that the value for HPV Δ8 E6 is statistically different from the similarly treated HPV 8 E6 cells as determined by student T-test with a p value ≤ 0.05. L denotes vector control (LXSN) HFKs. 5 denotes HPV 5 E6 expressing HFKs. 8 denotes HPV 8 E6 expressing HFKs. Δ8 denotes HPV Δ8 E6 expressing HFKs.