The Trojan family in chicken.

<p>A) <i>Mystran</i>, <i>Trojan</i> and <i>Thracian</i> on chicken chromosome Z. Genes are represented as hollow boxes showing their direction. Exons are shown as filled fragments within the gene boxes; B) The overall topology organization of the Trojan family proteins. Complement control protein (CCP) domains, fibronectin type III domains (FN3) and protein tyrosine phosphatase domains (PTP) are labeled. Signal peptides (SP), domains, transmembrane regions (TM), N-glycosylation (N-glyc) sites and intrinsically disordered (ID) binding sites are indicated. The Mystran CCP domain is shown in gray scale, as it was predicted slightly below threshold, but had the expected position. C) The cytoplasmic tails of Mystran, Trojan and Thracian are shown in a “snake” amino acids view. Short functional motifs are indicated: MAPK docking motif (DOC_MAPK), Grb association motif (LIG_SH_GRB), 14-3-3 docking motif (LIG_14-3-3), PKA phosphorylation motif (MOD_PKA), ITAM (LIG_TYR_ITAM) and TRAF2 interacting motif (LIG_TRAF2). For Thracian, the positions of cytoplasmic sites identified to be under positive evolutionary selection with probability higher than 90% and 95% (*) are indicated.