Circulatory clearance of bnAbs in macaques at different times after i.v. injection as measured by ELISA.

<p>Data are an average of two macaques. Each pharmacokinetics study was repeated once or twice. (A) Plasma levels (μ g/ml) following injection of mVRC01 at 5mg/kg (blue) or 10mg/kg (red) and VRC01 (10mg/kg, green). The insert shows clearance of the non-mutated VRC01 in each of two macaques on a different scale. (B) Average μ g/kg of two macaques injected with b12 (5 and 7.5 mg/kg), 10E8, 10–1074, PGT121 (each at 5mg/kg). The insert shows a comparison between 10–1074 and mNIH45–46^G54W both injected at 5mg/kg (C) Comparison of clearance of PGT121 (5mg/kg) as measured by ELISA (μ g/ml) and a pseudovirus-based TZM-bl assay against the RHPA4259.7 isolate (ID50) at different days following i.v. injection into macaques.