ARG1 deletion prevents Ang II-induced impairment in endothelium dependent vasorelaxation.

<p>Aortic rings were pre-constricted with phenylephrine (1 μM). Dashed line/filled circles indicate responses in WT Sham mice, dashed line/open circles indicate responses in Ang II-treated WT mice, solid line/open squares indicate responses in Ang II-treated ARG1^<b>+/−</b> mice, and solid line/filled squares indicate responses in ARG1^<b>+/−</b> Sham mice. <i>n</i> = 6 in each group; *<i>P</i>< 0.05 vs. other groups.